Evaluation of the Effect of Aqueous Extract of Olibanum on the Expression of FMR1 and MAP1B Genes in the Rat Hippocampus

نویسندگان

  • jebelli, asiyeh Dept of Biology, Higher Education Institute of Rab-Rashid, Tabriz, Iran
  • Mirbeygi, Seyed Younes Dept of Biology, Faculty of Basic Sciences, Tabriz Science and Research Branch, Islamic Azad University, Tabriz, Iran
  • Talebinejad Chavoshi, Elham Dept of Biology, Faculty of Basic Sciences, Tabriz Science and Research Branch, Islamic Azad University, Tabriz, Iran
چکیده مقاله:

Introduction: The therapeutic properties of Olibanum have been considered in traditional medicine since ages past. Recent studies indicated the effect of Olibanum on memory enhancement and prevention/treatment of Alzheimer's disease. Fragile X mental retardation protein is the product of the FMR1 gene that mediates memory formation through the development of communications between nerve cells. MAP1B is the FMRP target mRNA and its translation is inhibited by the effect of FMRP. Disturbance in the expression of FMR1 causes fragile X syndrome. Therefore, the aim of this study was to investigate the effect of aqueous extract of Olibanum on the expression of FMR1 and MAP1B genes in hippocampal tissue samples of rats.   Materials & Methods: This study was conducted on 18 rats which were divided into groups of control (n=6) and two treatment groups with 75 (n=6) and 150 mg/kg (n=6) concentrations of aqueous extract of Olibanum. The hippocampus of rats was isolated after eight weeks of treatment by Olibanum extract.  Total RNA was extracted and cDNA was synthesized in this study. Subsequently, the expression of FMR1 and MAP1B genes was evaluated by a real-time polymerase chain reaction. Ethics code:IR.TBZMED.REC.1396.1000   Findings: According to the results, the aqueous extract of Olibanum at a concentration of 75 mg/kg increased the expression of FMR1. In addition, MAP1B gene expression decreased in a dose-dependent manner following treatment with Olibanum extract. However, these changes are not statistically significant (P>0.05).   Discussion & Conclusions: The FMRP is a negative translation regulator that mediates synaptic neuronal transmission through inhibition translation of target mRNA, such as MAP1B. Olibanum probably leads to synaptic flexibility and memory improvement through increasing the expression of FMR1 in neuronal cells. This study could pave the way on the use of Olibanum in the treatment of patients with fragile X syndrome in the future.  

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation

in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 27  شماره 2

صفحات  64- 72

تاریخ انتشار 2019-06

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

کلمات کلیدی برای این مقاله ارائه نشده است

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023